'Wrong' subunit regulates cardiac potassium channels
نویسندگان
چکیده
منابع مشابه
Subunit composition of mink potassium channels
Expression of minK protein in Xenopus oocytes induces a slowly activating, voltage-dependent, potassium-selective current. Point mutations in minK that alter current gating kinetics, ion selectivity, pharmacology, and response to protein kinase C all support the notion that minK is a structural protein for a channel-type transporter. Yet, minK has just 130 amino acids and a single transmembrane...
متن کاملPharmacology of cardiac potassium channels.
Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of K+ ions across the cell membrane along its electrochemical gradient. They regulate the resting membrane potential, the frequency of pacemaker cells and the shape and duration of the cardiac action potential. Additionally, they have been recognized as potential targets for the actions of neurotransmitters and h...
متن کاملTitle Pharmacology of Cardiac Potassium Channels
Cardiac K channels are cardiomyocyte membrane proteins that regulate K ion flow across the cell membrane on the electrochemical gradient, and determine the resting membrane potential and the cardiac action potential morphology and duration. Several K channels have been well studied in the human heart. They include the transient outward K current Ito1, the ultra-rapidly delayed rectifier current...
متن کاملRemodeling of Potassium Channels in Cardiac Hypertrophy
B.I. Jugdutt and N.S. Dhalla (eds.), Cardiac Remodeling: Molecular Mechanisms, Advances in Biochemistry in Health and Disease 5, DOI 10.1007/978-1-4614-5930-9_2, © Springer Science+Business Media New York 2013 Abstract The potassium channel is a major target of remodeling in cardiac hypertrophy. To maintain physiological cardiac function in the face of increased workloads, hypertrophied cardiac...
متن کاملStructure and function of cardiac potassium channels.
Recent advances in molecular biology have had a major impact on our understanding of the biophysical and molecular properties of ion channels. This review is focused on cardiac potassium channels which, in general, serve to control and limit cardiac excitability. Approximately 60 K+ channel subunits have been cloned to date. The (evolutionary) oldest potassium channel subunits consist of two tr...
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ژورنال
عنوان ژورنال: Nature
سال: 1987
ISSN: 0028-0836,1476-4687
DOI: 10.1038/325296a0